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Custom gene analysis:
SNP and mutation screening by DNA sequencing
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Since
the completion of the Human Genome Project in the year 20011)
and the publication of the results, it is possible to screen
most human genomic sequences for mutations and polymorphisms.
Sequence comparison of patient and control groups often supplies
information on those changes in the genomic DNA that cause a
disease or a disposition to disease.
We provide custom genetic analysis of human DNA. On the basis of
published sequences, we develop and optimize amplification
protocols, isolate and sequence the amplified fragments to
perform the sequence comparison with the published GenBank data 2)
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The results of
the genetic analysis, and the methods developed are at the
unlimited disposal of our clients. As sample material we can use
genomic DNA, blood, tissue and preserved patient samples.
Please note that the patient's informed consent for the genetic
analysis of his DNA and, in case of research projects, the
consent of the university institute's ethical commission is
obligatory. The costs of the development of a custom gene
screening depend on the amount and the size of the gene
fragments and the number of samples to be analyzed.
Please contact
us for an initial project evaluation and price offer.
1)
The International Human Genome Sequencing Consortium (2001) The
human genome Nature 409: 813-958
2)
http://www.ncbi.nih.gov/Genbank/
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Rapid detection and
typing of
Ureaplasma urealyticum
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This bacterium is
thought to be involved in chronic lung disease and in
bronchopulmonary dysplasia (BPD) in premature infants.
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Ribotyping
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The amplification of ribosomal DNA
gene fragments and subsequent sequencing. E.g. to identify
unknown bacterial contaminations in biological products.
Ribotyping for the systematic characterization of plant species.
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Customer requests
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For special requests, like
development of a protocol for amplification of a specific gene,
please do contact us.
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our experience and infrastructure to speed up your
research! |
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